A Study on Lipid Profile and hs-CRP in Subclinical Hypothyroidism (Code-T0102)

Introduction: Subclinical hypothyroidism (SCH) is characterized by an elevated serum thyroid-stimulating hormone (TSH) level with normal thyroid hormone levels (T3 and T4). It is commonly associated with subtle metabolic disturbances, including alterations in lipid metabolism and inflammatory markers. Lipid profile abnormalities and increased high-sensitivity C-reactive protein (hs-CRP) levels have been linked to cardiovascular risk in SCH patients. This study aims to investigate the relationship between lipid profile and hs-CRP levels in individuals with subclinical hypothyroidism.

Aims and Objective:

1. To estimate the levels of hs-CRP and lipid profile in subjects with subclinical hypothyroidism.
2. To detect early cardiovascular abnormality..

Methods: This cross-sectional study included 100 subjects diagnosed with subclinical hypothyroidism based on elevated TSH levels. Lipid profile (total cholesterol, LDL, HDL, triglycerides) and hs-CRP levels were measured for all participants. The data were analyzed for any significant differences in lipid parameters and hs-CRP levels, and their correlation with TSH levels was explored.

Results: The results showed that subclinical hypothyroid patients had significant alterations in their lipid profile, with increased total cholesterol, LDL, and triglycerides, and decreased HDL levels. Additionally, hs-CRP levels were found to be elevated in these patients, indicating a potential inflammatory component associated with SCH.

Conclusion: Subclinical hypothyroidism is associated with dyslipidemia and elevated hs-CRP levels, suggesting an increased cardiovascular risk. Monitoring lipid profiles and hs-CRP could help in early detection and management of cardiovascular complications in SCH patients.

Keywords: Subclinical hypothyroidism, lipid profile, hs-CRP, cardiovascular risk, thyroid-stimulating hormone, inflammation.