Clinical Characteristics, Management, and Outcomes of Liver Abscess: A Study in a Tertiary Care Hospital (Code-T0110)

Introduction: Liver abscess, a potentially life-threatening condition, often arises from bacterial, parasitic, or fungal infections. Its clinical presentation varies, ranging from fever and abdominal pain to severe complications. Despite advancements in diagnostic and therapeutic modalities, liver abscess remains a challenge in resource-limited settings.

Aim and Objective

Aim:

 To study the treatment outcomes of patients with liver abscess in a tertiary care hospital. Objectives:

1. To analyze the clinical characteristics (demographics, abscess characteristics, and extent) of patients with liver abscess.
2. To identify complications and clinical presentations along with hematological and biochemical parameters.
3. To evaluate the treatment modalities used.
4. To compare the outcomes of different treatment approaches.

Methods: This retrospective study analyzed data from patients diagnosed with liver abscess over a two-year period at a tertiary care center. Clinical characteristics, including demographics, abscess size, location, and etiology, were recorded. Hematological and biochemical parameters were assessed alongside imaging findings. Treatment modalities, including antibiotics, percutaneous aspiration, and surgical drainage, were evaluated. Outcomes were compared based on the chosen treatment approach.

Results: A total of 120 patients were included, with a male predominance (70%). Pyogenic abscesses accounted for 60% of cases, while amoebic abscesses constituted 40%. Fever (85%) and abdominal pain (75%) were the most common symptoms. Percutaneous aspiration was performed in 40% of cases, with a success rate of 85%. Complications, including rupture and sepsis, were observed in 15% of cases. Patients managed with combined antibiotic therapy and percutaneous drainage had significantly better outcomes compared to antibiotics alone (p < 0.05).

Conclusion: Liver abscess management requires early diagnosis and a multidisciplinary approach. Combined antibiotic and interventional therapies improve outcomes, reducing morbidity and mortality.

Keywords: Liver abscess, pyogenic abscess, amoebic abscess, percutaneous aspiration, treatment outcomes, complications