Association of Serum Adenosine Deaminase and Glycated Hemoglobin in Type 2 Diabetes Mellitus (Code-T0119)

Introduction: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and associated systemic complications. Glycated hemoglobin (HbA1c) serves as a standard biomarker for assessing long-term glycemic control. Adenosine deaminase (ADA), an enzyme involved in purine metabolism and inflammation, has been implicated in the pathophysiology of diabetes. This study explores the association between serum ADA levels and HbA1c in patients with T2DM to assess their combined diagnostic and prognostic significance.

Aims and Objectives:

Aim: Study of serum ADA and glycated Hb in type 2 Diabetes Mellitus

Objectives:

1. To estimate the levels of serum ADA and Glycated Hb in patients of type 2 Diabetes Mellitus.

2. To compare the levels of serum ADA with controlled cases of DM and uncontrolled cases of Diabetes Mellitus.

3. To establish, if any, correlation between the levels of serum ADA with Glycated Hemoglobin.

Methods: A cross-sectional study was conducted on 150 participants, including 100 T2DM patients and 50 healthy controls. Serum ADA levels and HbA1c were measured using standard biochemical assays. Statistical analysis was performed to assess the correlation between ADA and HbA1c, and diagnostic efficacy was evaluated using receiver operating characteristic (ROC) analysis.

Results: Serum ADA levels were significantly higher in T2DM patients compared to controls (p < 0.001). A strong positive correlation was observed between ADA and HbA1c levels (r = 0.72, p < 0.01). ROC analysis revealed high sensitivity (87%) and specificity (85%) of ADA for identifying poor glycemic control.

Conclusion: Elevated serum ADA levels and their significant correlation with HbA1c suggest that ADA may serve as a complementary biomarker in the diagnosis and management of T2DM, reflecting both glycemic control and inflammatory status.

Keywords: Type 2 Diabetes Mellitus, Adenosine Deaminase, Glycated Hemoglobin, Biomarkers, Glycemic Control, Inflammation.