Histomorphological Spectrum of Melanoma and Nevus in the Skin, Mucosa, and Eye (Code-T0185)

Introduction: Melanomas and nevi are pigmented lesions that arise from melanocytes, with distinct histomorphological features. The study of their histology in various anatomical sites—such as the skin, mucosa, and eye—plays a crucial role in differentiating benign from malignant growths. Understanding the spectrum of these lesions in different locations can aid in early diagnosis and treatment.

Aims and Objectives:

Aim

To observe the histomorphological pattern of melanoma and nevus in skin,mucosa and eye with demographic study.

Objectives

1. Primary objective: To study the histomorphological pattern of melanoma and nevus in skin, mucosa and eye.
2. Secondary objective: To study the spectrum and age,sex and site distribution of melanoma

and nevus.

Methods: A retrospective analysis of biopsy specimens of melanoma and nevus from skin, mucosa, and eye tissues was conducted. Histopathological examination, including hematoxylin and eosin (H&E) staining and special immunohistochemical markers, was performed. The study included cases from both benign and malignant melanocytic lesions.

Results: The histological spectrum showed distinct features based on tissue type. Melanomas in the skin exhibited an irregular architecture with atypical melanocytes, while those in the mucosa and eye presented unique growth patterns. Nevi showed more uniform cellular arrangement with no significant mitotic activity, especially in the skin, compared to mucosal and ocular regions.

Conclusion: Histomorphological features of melanoma and nevus differ significantly based on their anatomical location. Awareness of these differences is vital for accurate diagnosis and management, particularly for distinguishing malignant melanomas from benign nevi in diverse tissues.

Keywords: Melanoma, Nevus, Histomorphology, Skin, Mucosa, Eye.