The Histomorphological Spectrum of Melanoma and Nevus in the Skin, Mucosal Tissues, and Eye (Code-T0188)

Introduction: Melanomas and nevi are both common melanocytic lesions, with the potential to present differently depending on their location. These lesions, which arise from melanocytes, show variable histomorphological features that can assist in differentiating benign from malignant growths. Their appearance in the skin, mucosal tissues, and eye presents unique diagnostic challenges that require careful histopathological evaluation.

Aims and Objectives: The aim of this study is to investigate the histomorphological spectrum of melanoma and nevus in the skin, mucosal tissues, and eye. The objective is to characterize the cellular features, growth patterns, and other microscopic distinctions between these lesions across various anatomical locations.

Methods: This study analyzed a series of melanoma and nevus cases from skin, mucosal tissues, and ocular sites. Histopathological evaluation, including hematoxylin and eosin (H&E) staining, along with immunohistochemistry, was used to assess the lesions for cellular morphology, tumor invasion, and other characteristic features.

Results: The results revealed distinct histological differences between melanomas and nevi, with melanomas demonstrating more cellular atypia, irregular growth patterns, and deeper tissue invasion. Nevi, in contrast, exhibited well-defined borders and uniform cellular structures, particularly in the skin. Notable differences were observed in mucosal and ocular sites where melanocytic lesions displayed unique growth patterns and cellular behaviors.

Conclusion: Histomorphological analysis plays a crucial role in distinguishing melanoma from nevus, especially in the skin, mucosa, and eye. Awareness of these differences aids in more accurate diagnosis and management of melanocytic lesions.

Keywords: Melanoma, Nevus, Histomorphology, Skin, Mucosal tissues, Eye.