To Assess the Systemic Manifestations of Leprosy and Evaluate the Adverse Effects of Anti-Leprosy Therapy in Newly Diagnosed Leprosy Patients - A Prospective Observational Study (Code-T0191)

Introduction: Leprosy is a chronic infectious disease caused by Mycobacterium leprae, known for its systemic manifestations and potential treatment-associated adverse effects. Despite advancements in multi-drug therapy (MDT), a detailed exploration of systemic impacts, including biochemical, cardiovascular, and psychological dimensions, remains lacking.

Aims and Objectives:

Aim:

To evaluate the systemic manifestations of Leprosy and evaluate the adverse effects of Anti Leprosy Therapy.

Primary Objectives:

1. To evaluate the systemic manifestations of Leprosy in newly diagnosed treatment naive patients.
2. To assess the adverse effects of Multi Drug Therapy (MDT).

Secondary objectives:

1. To determine the prevalence of systemic manifestations in newly diagnosed treatment naive Leprosy patients.
2. To compare the occurrence of systemic manifestations between Paucibacillary and Multibacillary Leprosy patients and its correlation with clinical outcomes.
3. To assess the adverse effects profile of Multi Drug Therapy.

Methods: This prospective observational study involves 50 newly diagnosed leprosy patients from a tertiary care center. Participants undergo comprehensive clinical, biochemical, and mental health assessments at baseline and at 3-month intervals until treatment completion. Investigations include electrocardiograms, 2D echocardiography, serum calcium and magnesium levels, and standardized mental health questionnaires.

Results: Data analysis will determine the prevalence of systemic manifestations, electrolyte imbalances, and the mental health burden of leprosy patients. Early findings suggest that chronic inflammation may lead to significant biochemical alterations, while MDT could exacerbate metabolic disturbances.

Conclusion: This study highlights the systemic impacts of leprosy and the need for a multidisciplinary approach to patient care. Insights into adverse effects and systemic changes can inform tailored therapeutic strategies, improving outcomes and quality of life.

Keywords: Leprosy, systemic manifestations, multi-drug therapy, electrolyte imbalance, cardiovascular health, mental health.