Assessment of Resistin Levels in Type 2 Diabetes Mellitus (code: T0001)

Introduction: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder marked by persistent hyperglycemia and insulin resistance, contributing significantly to global health burdens. Resistin, an adipokine linked to inflammation and metabolic dysfunction, is gaining attention as a potential biomarker for T2DM progression and complications.

AIM & OBJECTIVES

The aim of present study is to estimate the levels of serum Resistin in type 2 Diabetes mellitus and healthy controls .

Materials and Methods: A case-control study was conducted at Dr. Rajendra Prasad Government Medical College, Kangra, involving 60 patients diagnosed with T2DM and 60 healthy controls matched for age and gender. Biochemical parameters, including serum resistin, fasting blood glucose (FBS), glycated hemoglobin (HbA1c), and lipid profiles, were measured. Statistical analyses, such as t-tests and Pearson’s correlation coefficients, were used to determine group differences and correlations between resistin levels and other biochemical variables.

Results: The mean serum resistin level was significantly higher in T2DM patients (16.32 ng/mL) compared to healthy controls (7.15 ng/mL), with a large effect size (Cohen’s d = 3.45, p < 0.001). Additionally, diabetic patients showed elevated FBS, HbA1c, triglycerides, and low-density lipoprotein (LDL) levels, with reduced high-density lipoprotein (HDL) levels compared to controls. Correlation analysis demonstrated a moderate positive correlation between resistin and age (r = 0.59) and weak correlations with lipid and glycemic parameters.

Conclusion: The significantly elevated serum resistin levels in T2DM patients suggest its potential role in the inflammatory pathways associated with diabetes rather than direct glucose metabolism. Resistin’s association with age highlights the need for further research into its role in aging-related metabolic inflammation and T2DM progression.