To Study the Effect of Preemptive Celecoxib for Postoperative Analgesia in Spine Surgery (Code-T0200)

Introduction: Effective postoperative analgesia is critical for recovery following spine surgery. Preemptive analgesia, administered before the onset of pain, may reduce postoperative pain intensity and the need for opioids. Celecoxib, a selective COX-2 inhibitor, is a promising option due to its anti-inflammatory and analgesic properties with a favorable safety profile.

Aims and Objectives:

Aim
The aim of this study is to evaluate the analgesic effect of preemptive administration of Celecoxib on postoperative pain in patients undergoing spine surgery.

Objectives

1. To assess the effect of preemptive analgesia with Celecoxib on postoperative pain.
2. To determine the required dose of narcotic drugs for pain management.

Methods: This prospective, randomized, controlled trial included 100 patients undergoing elective spine surgery. Participants were randomized into two groups: the celecoxib group (200 mg orally 2 hours preoperatively) and a control group (placebo). Postoperative pain was assessed using the Visual Analog Scale (VAS) at 2, 6, 12, and 24 hours. Opioid consumption and time to first rescue analgesia were recorded.

Results: Patients in the celecoxib group reported significantly lower VAS scores at all time points (p < 0.05). Total opioid consumption was reduced by 30%, and the time to first rescue analgesia was significantly prolonged compared to the control group. No significant adverse effects were observed.

Conclusion: Preemptive celecoxib effectively reduces postoperative pain and opioid consumption in spine surgery patients, enhancing recovery and patient satisfaction. Its favorable safety profile supports its routine use as part of multimodal analgesia strategies.

Keywords: Preemptive analgesia, celecoxib, spine surgery, postoperative pain, opioid consumption, multimodal analgesia.