Comparison of Subconjunctival Injection with Sponge Application of Mitomycin C in Two-Site Phacotrabeculectomy: A Randomized Controlled Trial (Code-T0202)

Introduction: Phacotrabeculectomy is a combined procedure for cataract and glaucoma surgery. Mitomycin C (MMC) is often used to enhance the success rate of filtration surgery by preventing scarring. There are two common methods for applying MMC: subconjunctival injection and sponge application. This study aims to compare the efficacy and safety of these two techniques in two-site Phacotrabeculectomy.

Aims and Objectives:The primary aim of this study is to compare the outcomes of subconjunctival injection versus sponge application of MMC in two-site Phacotrabeculectomy. The secondary objective is to evaluate the complications, intraocular pressure (IOP), and surgical success rates following both methods.

Methods: This randomized controlled trial included 60 patients with primary open-angle glaucoma undergoing two-site Phacotrabeculectomy. The patients were randomly assigned to receive either a subconjunctival injection or sponge application of MMC during the surgery. Postoperative evaluation was performed at 1 week, 1 month, and 3 months, focusing on IOP control, complications, and the need for further interventions.

Results: The results indicated that both subconjunctival injection and sponge application of MMC effectively controlled IOP. However, sponge application showed a slightly higher success rate with fewer complications, such as conjunctival edema and infection. Both methods were well tolerated.

Conclusion: Sponge application of MMC appears to offer better outcomes in terms of surgical success and fewer complications compared to the subconjunctival injection method in two-site Phacotrabeculectomy.

Keywords: Phacotrabeculectomy, Mitomycin C, Subconjunctival Injection, Sponge Application, Glaucoma Surgery, Randomized Controlled Trial.