Echocardiographic and Tissue Doppler Findings in Heart Failure with Preserved Ejection Fraction (HFpEF) and Their Association with NT-ProBNP Levels (Code-T0207)

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome characterized by diastolic dysfunction and elevated filling pressures despite normal left ventricular ejection fraction (LVEF). Echocardiography and tissue Doppler imaging (TDI) play crucial roles in diagnosing and assessing HFpEF. NT-ProBNP, a biomarker for myocardial stress, is often elevated in HFpEF patients. This study aims to evaluate echocardiographic and TDI findings in HFpEF patients and their correlation with NT-ProBNP levels.

Aims and Objectives:

• To study the echocardiographic and Tissue Doppler imaging findings in patients of Heart Failure with Preserved Ejection Fraction(HFprEF)
• To study the levels of NT-proBNP in patients with HFprEF
• To establish a correlation between the echocardiographic and tissue Doppler imaging findings and NTproBNP levels in patients with HFprEF

Methods: A cross-sectional study was conducted on patients diagnosed with HFpEF based on clinical criteria and echocardiographic findings. Conventional echocardiographic parameters such as left atrial volume index, E/e’ ratio, and diastolic dysfunction markers were assessed. TDI was used to evaluate myocardial relaxation velocities. NT-ProBNP levels were measured, and their correlation with echocardiographic indices was analyzed.

Results: Patients with higher NT-ProBNP levels exhibited increased left atrial volume, higher E/e’ ratios, and reduced e’ velocities on TDI, indicating greater diastolic dysfunction. A significant correlation was observed between NT-ProBNP levels and echocardiographic parameters reflecting elevated left ventricular filling pressures.

Conclusion: Echocardiographic and TDI findings provide valuable insights into HFpEF pathophysiology. NT-ProBNP levels correlate strongly with diastolic dysfunction markers, reinforcing their role in HFpEF diagnosis and prognostication.

Keywords: HFpEF, Echocardiography, Tissue Doppler Imaging, NT-ProBNP, Diastolic Dysfunction, Heart Failure