Association Between Aggression and CRP-to-Albumin Ratio in Patients with Schizophrenia (Code-T0216)

Introduction: Schizophrenia is a chronic psychiatric disorder often associated with aggression, which complicates disease management and social functioning. Emerging evidence suggests that systemic inflammation plays a role in schizophrenia, with C-reactive protein (CRP) and albumin serving as potential biomarkers. The CRP-to-albumin ratio (CAR) is an inflammatory marker that reflects both acute-phase response and nutritional status. This study investigates the association between CAR and aggression in patients with schizophrenia.

Aim and Objectives:

1. To study CRP levels and albumin levels in patients of schizophrenia (diagnosed as per ICD11)
2. To evaluateaggression in patients of schizophrenia.
3. To study relationship between Aggression in Schizophrenia with CRP/Albumin ratio.

Methods: A cross-sectional study was conducted on schizophrenia patients diagnosed per DSM-5 criteria. Participants were stratified based on aggression levels using validated scales. Blood samples were collected to measure CRP and albumin levels, and CAR was calculated. Statistical analysis was performed using SPSS, with p<0.05 considered significant.

Results: Patients with higher aggression scores had significantly elevated CAR values compared to non-aggressive patients (p<0.001). A positive correlation was observed between CAR and aggression severity, suggesting that systemic inflammation may contribute to aggressive behaviors in schizophrenia.

Conclusion: CAR is a promising biomarker for aggression in schizophrenia, reflecting underlying inflammation and nutritional status. Routine CAR assessment may help identify high-risk patients and guide targeted interventions to improve disease management.

Keywords: Schizophrenia, aggression, inflammation, CRP-to-albumin ratio, psychiatric biomarkers, systemic inflammation.