Evaluation of Preemptive Celecoxib for Postoperative Analgesia in Spine Surgery(Code-T0219)

Introduction: Effective pain management after spine surgery is crucial for patient recovery and rehabilitation. Nonsteroidal anti-inflammatory drugs (NSAIDs) like celecoxib, a selective COX-2 inhibitor, have been explored for preemptive analgesia to reduce postoperative pain and opioid consumption. However, its efficacy in spine surgery remains under investigation. This study evaluates the effect of preemptive celecoxib on postoperative pain relief and analgesic requirements in spine surgery patients.

Aim and Objectives:

Aim:
The aim of this study is to determine the analgesic effect of preemptive administration of celecoxib on postoperative pain in patients undergoing spine surgery.

Objectives:

1. To evaluate the effectiveness of preemptive celecoxib in reducing postoperative pain.
2. To assess the impact of preemptive celecoxib on the requirement of narcotic analgesics postoperatively.

Methods: A randomized controlled study was conducted on patients undergoing elective spine surgery. Participants were divided into two groups: Group C (received preemptive celecoxib 200 mg orally 1 hour before surgery) and Group P (placebo). Pain scores using the Visual Analog Scale (VAS), total opioid consumption, and adverse effects were recorded at 6, 12, and 24 hours postoperatively. Statistical analysis was performed using SPSS, with p<0.05 considered significant.

Results: Patients in the celecoxib group had significantly lower VAS pain scores and reduced opioid consumption compared to the placebo group (p<0.001). No significant increase in adverse effects was observed.

Conclusion: Preemptive celecoxib effectively reduces postoperative pain and opioid requirements in spine surgery without increasing adverse effects, making it a valuable addition to multimodal analgesia strategies.

Keywords: Celecoxib, preemptive analgesia, spine surgery, postoperative pain, opioid consumption, NSAIDs.