A Prospective Study on the Clinico-Etiological Profile, Progression, and Outcomes of Hepatorenal Syndrome in Patients with Decompensated Chronic Liver Disease and the Prognostic Value of the MELD Score in a Tertiary Care Hospital (Code-T0230)

Introduction: Hepatorenal Syndrome (HRS) is a severe complication of decompensated chronic liver disease (DCLD), characterized by functional renal failure in the absence of structural kidney disease. The Model for End-Stage Liver Disease (MELD) score is widely used for assessing disease severity and predicting patient outcomes. Understanding the clinico-etiological profile and progression of HRS is crucial for improving management and prognosis.

Aims and Objectives:

Primary Objective:

To study the clinico-etiological profile, course and the outcome of hepatorenal syndrome in decompensated chronic liver disease patients.

Secondary Objective:

To study the clinical and biochemical parameters on admission and its association with the clinical outcome of hepatorenal syndrome patients.

The prognostic significance of MELD score in these patients in reversal and in hospital mortality.

Methods: A prospective study was conducted on patients diagnosed with HRS secondary to DCLD at a tertiary care hospital. Data on demographic details, clinical presentation, laboratory findings, etiology of liver disease, and disease progression were collected. Patients were classified based on HRS type and their MELD scores were recorded. Outcomes, including mortality and renal function recovery, were analyzed.

Results: The study is expected to demonstrate that a higher MELD score correlates with increased disease severity and poor prognosis. The predominant causes of DCLD leading to HRS include alcohol-related liver disease and viral hepatitis. The mortality rate is anticipated to be high, with limited renal recovery in advanced cases.

Conclusion: Early identification and management of HRS in DCLD patients are critical. The MELD score serves as a reliable predictor of outcomes, guiding treatment decisions and liver transplantation prioritization.

Keywords: Hepatorenal syndrome, Chronic liver disease, Decompensated cirrhosis, MELD score, Prognosis, Renal dysfunction.