A Study on Renal Failure In Chronic Liver (Code-T0231)

Background: Chronic liver disease (CLD) is a significant health concern that can lead to various complications, including renal failure. The pathophysiological relationship between CLD and renal failure is complex, involving multifactorial mechanisms that include altered hemodynamics, inflammation, and kidney injury.

Aim and Objectives:

To identify the precipitating /risk factors associated with the renal

failure in patients with chronic liver disease

2. To study the clinical profile in patients with cirrhosis who developed

the renal failure

3. To assess the outcome of renal failure on mortality in a period of two

weeks of follow up ( in hospital mortality).

Methods: A cross-sectional study was conducted at a tertiary care hospital, involving 100 patients diagnosed with CLD. Data on demographics, liver function tests, renal parameters, and comorbidities were collected. Renal failure was defined based on serum creatinine levels and urine output. The relationship between liver disease progression and renal failure was analyzed using statistical methods.

Results: Of the 100 CLD patients, 40% showed evidence of renal dysfunction. Among these, 25% had acute kidney injury (AKI) while 15% presented with chronic kidney disease (CKD). The severity of liver disease, as indicated by cirrhosis and ascites, correlated significantly with the development of renal failure. The most common causes of renal failure in these patients included hepatorenal syndrome (HRS) and drug-induced nephrotoxicity.

Conclusion: Renal failure is a common complication in patients with chronic liver disease, particularly those with advanced liver dysfunction. Early detection and management of kidney injury are essential to improve outcomes and reduce mortality.

Keywords: Chronic liver disease, renal failure, hepatorenal syndrome, acute kidney injury, cirrhosis, kidney dysfunction.