A Study on Parameters of Hepatorenal Dysfunction in Cases of Decompensated Chronic Liver Disease at a Tertiary Care Centre (Code-T0232)

Background: Hepatorenal dysfunction is a significant complication in patients with decompensated chronic liver disease (DCLD), contributing to increased morbidity and mortality. The interaction between liver and kidney dysfunction is critical in determining the clinical outcomes in these patients. Understanding the parameters involved in this dysfunction can guide better management strategies.

Aim and Objectives:

1. A study on parameters of Hepatorenal Dysfunction in cases of DCLD at a Tertiary Care Centre
2. To study the complication of DCLD

Primary Objective-

Role of cystatin C in Hepatorenal Dysfunction case of Cirrhosis.

Secondary Objectives-

1. To study the prevalence of causes of DCLD
2. To study the frequency of complication of DCLD
3. To study the advantages of Cystatic over Serum creatinine by using eGFR

Methods: A cross-sectional observational study was conducted at a tertiary care centre involving 120 patients diagnosed with DCLD. Data regarding liver function tests, renal parameters (serum creatinine, blood urea nitrogen, urine output), and associated clinical findings were collected. Hepatorenal syndrome (HRS) was diagnosed based on defined clinical criteria. Statistical analyses were performed to examine the association between liver severity and renal dysfunction.

Results: Among the 120 DCLD patients, 45% exhibited varying degrees of renal dysfunction. Hepatorenal syndrome was diagnosed in 30% of cases, with a strong correlation between the severity of liver disease (ascites, jaundice, encephalopathy) and renal impairment. Elevated serum creatinine and decreased urine output were the most consistent findings associated with renal dysfunction.

Conclusion: Hepatorenal dysfunction is common in patients with DCLD, with hepatorenal syndrome being the leading cause of renal failure in these patients. Monitoring renal parameters closely and early identification of hepatorenal syndrome can improve patient outcomes and reduce mortality.

Keywords: Hepatorenal dysfunction, decompensated chronic liver disease, hepatorenal syndrome, renal failure, liver function tests, serum creatinine.