A Study on Assessment of Renal Functions in Patients with Chronic Liver Disease at a Tertiary Care Hospital (CODE-T233)

Background: Chronic liver disease (CLD) is a prevalent condition that often leads to renal complications, significantly impacting patient outcomes. The relationship between liver dysfunction and renal impairment, particularly in advanced stages, is complex and requires careful monitoring to ensure optimal management.

Aim and Objectives:

Evaluation of renal function tests to find the incidence of various types of acute renal failure in chronic liver disease patients.

 Causal relationship of various factors for different types of acute renal failure in chronic liver disease patients.

 Evaluate the diagnostic accuracy of plasma creatinine levels in assessing renal functions in patients of chronic liver disease.

Methods: A prospective observational study was conducted at a tertiary care hospital, involving 150 patients diagnosed with CLD. Renal function was assessed using serum creatinine levels, blood urea nitrogen, urine output, and glomerular filtration rate (GFR). Liver function was evaluated using liver enzymes, bilirubin levels, and prothrombin time. The data were analyzed to establish a correlation between the severity of liver disease and renal impairment.

Results: Out of 150 patients, 50% presented with varying degrees of renal dysfunction. The most common renal abnormalities observed were increased serum creatinine and reduced urine output. The incidence of renal dysfunction was significantly higher in patients with cirrhosis, ascites, and advanced stages of liver disease. Hepatorenal syndrome was identified in 35% of patients with severe renal impairment.

Conclusion: Renal dysfunction is common in patients with chronic liver disease, especially in those with advanced cirrhosis. Regular monitoring of renal parameters is crucial for early detection and management of complications, including hepatorenal syndrome, to improve patient prognosis.

Keywords: Chronic liver disease, renal function, hepatorenal syndrome, serum creatinine, liver cirrhosis, glomerular filtration rate.