Cross-Sectional Observational Study to Assess Patterns of Adverse Drug Reactions Linked to Antipsychotic Medication Use (Code-T0236)

Introduction: Antipsychotic medications are commonly prescribed for the treatment of various psychiatric disorders; however, their use is frequently associated with adverse drug reactions (ADRs). Understanding the nature and frequency of these reactions is essential for improving patient care and minimizing risks.

Aim and Objective:

Aim - to determine the severity of ADR’s associated with antipsychotic medication(s).

• Primary objective – to assess ADRs associated with antipsychotic medications using Hartwig scale.
  • Secondary objective(s) – To identify the drug with the most severe ADR’s.
  • To identify the drug with maximum number of ADR’s.
  • To identify the most common ADR observed with each drug.
  • To assess the preventability of the ADR’s using Modified Schumock Thornton scale.

Methods: A cross-sectional observational study was conducted at a tertiary care hospital over a six-month period. Data was collected from patients prescribed antipsychotic medications through patient records and direct interviews. ADRs were identified using standardized reporting forms, and their frequency and severity were assessed. Demographic and clinical factors were also considered.

Results: A total of 150 patients were included in the study. The most common ADRs were weight gain (30%), sedation (22%), and extrapyramidal symptoms (15%). Factors such as age, comorbidities, and medication type were identified as significant contributors to ADRs. A notable proportion of patients (18%) reported discontinuing medication due to intolerable side effects.

Conclusion: The study highlights the prevalence of ADRs in patients using antipsychotic medications, emphasizing the need for vigilant monitoring and personalized treatment approaches. Addressing these issues can help improve adherence and patient outcomes in psychiatric care.

Keywords: Antipsychotic medications, adverse drug reactions, cross-sectional study, extrapyramidal symptoms, patient outcomes, medication adherence.