Role of Granulocyte Colony-Stimulating Factor in Enhancing Endometrial Receptivity in Women Undergoing Ovulation Induction (Code-T0262)

Introduction: Endometrial receptivity plays a crucial role in the success of assisted reproductive technologies (ART) and natural conception. Granulocyte Colony-Stimulating Factor (G-CSF) has emerged as a potential therapeutic agent to improve endometrial receptivity in women undergoing ovulation induction, particularly in cases of recurrent implantation failure. This study explores the role of G-CSF in enhancing endometrial receptivity and its potential impact on pregnancy outcomes.

Aims and Objectives:

Aim:

To Study The Effect Of Intrauterine Instillation Of G- Csf In Infertile Women With Poor Endometrial Receptivity.

Objectives:

1. To measure the endometrial thickness and endometrial vascularity of patient undergoing ovulation induction after G- CSF administration.

2. To correlate the effectiveness of G-CSF in improving endometrial receptivity in women undergoing ovulation induction.

Methods: A prospective, randomized controlled trial was conducted involving 120 women undergoing ovulation induction for ART. Participants were randomly assigned to receive either G-CSF injections or a placebo during the peri-implantation window. Endometrial thickness and blood flow were assessed using ultrasonography. Pregnancy outcomes, including implantation and live birth rates, were monitored.

Results: The G-CSF group demonstrated a significantly higher endometrial thickness (p<0.05) and improved endometrial blood flow compared to the placebo group. Clinical pregnancy rates were higher in the G-CSF group (45%) compared to the placebo group (30%). Furthermore, live birth rates were also significantly improved in the G-CSF group.

Conclusion: G-CSF appears to enhance endometrial receptivity and improve clinical pregnancy and live birth rates in women undergoing ovulation induction. This suggests its potential as an adjunct therapy in ART for women with implantation failure.

Keywords: Granulocyte Colony-Stimulating Factor, Endometrial receptivity, Ovulation induction, Recurrent implantation failure, Pregnancy outcomes, Assisted reproductive technology.