To Study the Role of Cerebral Perfusion Using 3 Tesla Arterial Spin Labeling Magnetic Resonance Imaging in Dementia Patients (Code-T0282)

Introduction: Dementia is a progressive neurocognitive disorder affecting memory, reasoning, and daily functioning. Accurate diagnosis is essential for early intervention. Arterial Spin Labeling (ASL) MRI is a non-invasive imaging modality that measures cerebral blood flow (CBF), offering insights into vascular contributions to dementia.

Aims and Objectives:

Aim

To study the Role of cerebral perfusion using 3 Tesla Arterial Spin Labeling Magnetic Resonance Imaging in dementia patients

Objectives:

• To estimate the pattern of cerebral perfusion in different areas in patients with dementia using ASL MRI.
• To determine whether cognitive impairment and cerebral hypoperfusion in dementia are related.
• To determine the pattern of cerebral perfusion in different areas in dementia patients as compared to those who are cognitively normal.
• To determine the correlation between the levels of cognitive impairment and cerebral hypoperfusion in dementia patients using 3 Tesla ASL MRI

Methods: A cross-sectional study will be conducted on 70 subjects, including 35 dementia patients diagnosed using DSM-5 criteria and 35 age- and gender-matched healthy controls. Participants will undergo ASL MRI to assess regional cerebral perfusion patterns. Statistical analysis will evaluate correlations between perfusion deficits and cognitive function.

Results: The study anticipates detecting hypoperfusion in key brain regions associated with dementia, including the temporoparietal and frontal lobes. A significant correlation between reduced CBF and cognitive decline severity is expected, supporting ASL MRI as a valuable diagnostic tool.

Conclusion: ASL MRI is a promising non-invasive imaging modality for evaluating cerebral perfusion in dementia. It may aid in early diagnosis, differentiate between dementia subtypes, and provide insights into disease progression, contributing to improved patient management.

Keywords: Dementia, Arterial Spin Labeling, Cerebral Perfusion, MRI, Cognitive Impairment, Neuroimaging