Therapeutic Plasma Exchange: Efficacy, Outcomes, and Applications in Immunological and Non-Immunological Disorders (Code-T0294)

Introduction: Therapeutic Plasma Exchange (TPE) is an extracorporeal blood purification technique used in various immunological and non-immunological disorders. It helps in removing pathogenic substances, modulating immune responses, and supporting organ function. TPE has gained significance in conditions like autoimmune diseases, neurological disorders, and acute liver failure, where conventional treatments alone may not suffice.

Aims and Objectives:

Aim

To study the Efficacy of Therapeutic Plasma Exchange for Immunological and  Non- immunological cases.

Objectives

1. To study the   Indications  and  Category of  PLEX  performed  in our centre.
2. To study the outcomes in clinical and  laboratory parameters after 
3. To study the Safety and Adverse events during PLEX procedure.

Methods: A prospective observational study was conducted at a tertiary care hospital. Patients undergoing TPE for various indications were included. Clinical and laboratory parameters were recorded before and after TPE sessions. Adverse effects and patient responses were documented. Statistical analysis was performed using appropriate tests to determine the significance of changes in outcomes.

Results: TPE showed significant improvement in patients with autoimmune disorders like Guillain-Barré Syndrome, Myasthenia Gravis, and thrombotic thrombocytopenic purpura. In non-immunological conditions, such as acute liver failure and hyperviscosity syndromes, TPE provided symptomatic relief and improved laboratory markers. Adverse reactions were minimal, with hypotension and citrate-related effects being the most common.

Conclusion: TPE is an effective therapeutic modality for a wide range of disorders, contributing to better patient outcomes. Early intervention with TPE can enhance recovery and serve as a bridge to definitive treatments like immunosuppression or organ transplantation.

Keywords: Therapeutic Plasma Exchange, Autoimmune Disorders, Acute Liver Failure, Guillain-Barré Syndrome, Hyperviscosity Syndrome, Immunomodulation