Comparative Analysis of Cardiometabolic Index, Lipid Accumulation Product, and Atherogenic Index of Plasma Across Metabolic Obesity Phenotypes and Their Association with FTO-rs9939609 Polymorphism (Code-T0301)

Introduction: Obesity is a major global health concern linked to various cardiometabolic disorders, including type 2 diabetes mellitus, hypertension, and cardiovascular disease. However, not all individuals with obesity have the same metabolic risk. The concept of metabolically healthy obesity (MHO) versus metabolically unhealthy obesity (MUO) has gained attention in recent years. Metabolic indices such as the cardiometabolic index (CMI), lipid accumulation product (LAP), and atherogenic index of plasma (AIP) are valuable tools for assessing cardiometabolic risk. The fat mass and obesity-associated (FTO) gene, particularly the rs9939609 polymorphism, has been implicated in obesity and metabolic dysfunction. This study aims to explore the association between these indices and the FTO-rs9939609 polymorphism across different metabolic obesity phenotypes.

Aims and Objectives

Aims: This study aims to investigate the variations in cardiometabolic index, lipid accumulation product, and atherogenic index of plasma across different metabolic phenotypes of obesity. Furthermore, it seeks to explore the relationship between these indices and the FTO-rs9939609 polymorphism, stratifying results by age and genotype to gain a more comprehensive understanding of the interactions between genetic predisposition, metabolic health, and obesity.

Objective: The study aims to compare cardiometabolic index (CMI), atherogenic index of plasma (AIP), lipid accumulation product (LAP) and novel anthropometric indices in metabolically healthy and metabolically unhealthy obese individuals with regard to the role of FTO gene.

Methods: A comparative study was conducted on 180 obese individuals categorized into MHO and MUO groups. Anthropometric indices and biochemical markers were analyzed, and FTO gene polymorphism was assessed using RT-PCR. Statistical analysis was performed using SPSS, with p < 0.05 considered significant.

Results: MUO individuals exhibited significantly higher CMI, LAP, and AIP values compared to MHO individuals. The AA allele of FTO-rs9939609 was more prevalent in MUO individuals, suggesting a genetic predisposition to metabolic unhealthiness.

Conclusion: Metabolic indices and FTO polymorphism play a crucial role in distinguishing metabolic obesity phenotypes. These findings highlight the need for genetic and metabolic risk assessment in obesity management.

Keywords: Metabolically Healthy Obesity, Metabolically Unhealthy Obesity, Cardiometabolic Index, Lipid Accumulation Product, Atherogenic Index of Plasma, FTO Gene Polymorphism