Comparison of Central Corneal Thickness in Glaucoma Subjects and Non-Glaucoma Subjects: A Prospective Study (Code-T0306)

Introduction: Central corneal thickness (CCT) is a crucial parameter in assessing intraocular
pressure (IOP) and plays a significant role in glaucoma diagnosis and management. Thinner
corneas may lead to an underestimation of IOP, increasing the risk of undiagnosed glaucoma,
while thicker corneas may overestimate IOP, affecting treatment decisions. This study aims to
compare CCT between glaucoma and non-glaucoma subjects and evaluate its impact on IOP
measurement.
Aims and Objectives:
Aim: To evaluate the effect of central corneal thickness on Intraocular pressure (IOP).
Objectives
1. To compare central corneal thickness between glaucoma subjects and non glaucoma subjects.
2. To determine relationship of central corneal thickness to intraocular pressure.
Methods: This prospective study was conducted on 364 eyes (182 glaucoma and 182 nonglaucoma
subjects) at a tertiary care center. CCT was measured using ultrasonic pachymetry, and
IOP was recorded using Goldmann applanation tonometry (GAT). Statistical analysis was
performed to evaluate the correlation between CCT and IOP.
Results: The mean CCT in glaucoma subjects was significantly lower (0.5 ± 0.036 μm)
compared to non-glaucoma subjects (0.53 ± 0.029 μm, p<0.001). Glaucoma subjects also had
higher mean IOP (20.19 ± 7.54 mmHg) compared to non-glaucoma subjects (16.09 ± 1.73
mmHg, p<0.001). A strong negative correlation between CCT and IOP was observed.
Conclusion: Glaucoma patients tend to have thinner corneas, which may lead to an
underestimation of IOP. Incorporating CCT measurements in glaucoma screening can improve
diagnostic accuracy and treatment planning.
Keywords: Central Corneal Thickness, Glaucoma, Intraocular Pressure, Ultrasonic Pachymetry,
Goldmann Applanation Tonometry, Ocular Biomechanics.