To Evaluate the Expression of the EGR2 Gene in Term Low Birth Weight Newborns (Code-T0030)

Introduction: Low birth weight (LBW) is a significant factor contributing to neonatal morbidity and mortality. Various genetic factors have been implicated in the development of LBW, with the EGR2 gene playing a potential role in regulating growth and development. The EGR2 gene, a transcription factor, has been linked to the regulation of cellular growth and differentiation. This study aims to evaluate the expression of the EGR2 gene in term LBW newborns.

Aims and Objectives

• To evaluate the role of expression of EGR2 Gene in Term LBW Newborns.
• To study the various risk factor for LBW Newborns.

Methods: This case-control study included 42 term LBW newborns and 42 healthy newborns with normal birth weight. RNA was extracted from cord blood samples, and the expression levels of the EGR2 gene were quantified using quantitative PCR (qPCR). Data were analyzed to compare the gene expression levels between the two groups, and any correlations with clinical variables, such as birth weight and gestational age, were also explored.

Results: The expression of the EGR2 gene was significantly lower in the LBW group compared to the normal birth weight group. A negative correlation was found between EGR2 expression levels and birth weight, suggesting a potential role of the EGR2 gene in fetal growth regulation.

Conclusion: The reduced expression of the EGR2 gene in term LBW newborns highlights its potential involvement in impaired fetal growth. Further studies are required to elucidate the precise role of EGR2 in LBW and its implications for neonatal health.

Keywords: EGR2 Gene, Low Birth Weight, Gene Expression, Neonatal Outcomes, Fetal Growth, Quantitative PCR.