The evaluation of serum prolactin levels in connective tissue disorders patients with dermatological manifestations – a cross-sectional study (Code-T0322)

Introduction: Connective tissue disorders (CTDs) are a group of autoimmune conditions 
affecting multiple organ systems, including the skin. Prolactin, a polypeptide hormone produced 
by the pituitary gland and immune cells, has been implicated in autoimmunity. Elevated serum 
prolactin levels have been observed in various CTDs, suggesting a potential role in their 
pathogenesis. However, limited data exist on the correlation between serum prolactin levels and 
disease activity in Indian patients. 
Aims and Objectives 
1. To compare the values of serum prolactin levels among patients of connective tissue 
disorders with controls. 
2. To assess the activity of disease in patients with hyperprolactinemia in connective 
tissue disorders. 
Methods: A cross-sectional study was conducted at Vydehi Institute of Medical Sciences & 
Research Centre. Sixty patients diagnosed with CTDs and presenting with skin manifestations 
were included. Serum prolactin levels were measured using venous blood samples, and clinical 
disease activity was assessed. Data were statistically analyzed using SPSS software. 
Results: The study found a significant elevation of serum prolactin levels in CTD patients 
compared to controls. Hyperprolactinemia was associated with increased disease activity, 
suggesting a potential immunomodulatory role of prolactin in CTDs. 
Conclusion: Serum prolactin may serve as a biomarker for disease activity in CTD patients with 
dermatological manifestations. Further research is needed to explore its therapeutic implications 
in autoimmune disorders. 
Keywords: Connective Tissue Disorders, Prolactin, Autoimmunity, Dermatology, Biomarkers, 
Disease Activity.