Prevalence of NAFLD in Moderate and Severe Hemophilia (Code-T0325)

Introduction: Hemophilia A and B are congenital coagulation disorders associated with 
increased morbidity due to bleeding complications. In recent years, the prevalence of non
alcoholic fatty liver disease (NAFLD) has risen, becoming a significant concern among persons 
with hemophilia (PWH). Factors such as obesity, metabolic syndrome, and past exposure to 
contaminated blood products contribute to liver disease in this population. However, data on 
NAFLD prevalence in PWH, especially in India, remain limited. 
Aims and Objectives 
This study aims to determine the prevalence of NAFLD in patients with moderate and severe 
hemophilia. Additionally, it seeks to evaluate the risk factors associated with NAFLD in this 
population. 
Methods: A cross-sectional study will be conducted at IMS-BHU, Varanasi. Patients with 
moderate (clotting factor activity 1–5%) and severe hemophilia (clotting factor activity <1%) 
will be included. Exclusion criteria will encompass alcohol consumption, autoimmune diseases, 
and hepatitis B or C infections. Data collection will involve clinical history, laboratory 
investigations (ALT, AST, liver function tests), and imaging (ultrasound and Fibroscan) for 
NAFLD diagnosis. Statistical analysis will be performed using SPSS v20.0. 
Results: The study anticipates a higher prevalence of NAFLD in hemophiliacs than in the 
general population, particularly among those with obesity and metabolic syndrome. A correlation 
between NAFLD and liver enzyme alterations is expected. 
Conclusion: NAFLD poses a significant health risk in hemophiliacs. Early screening and 
lifestyle modifications may help prevent disease progression. Further research is needed to 
understand the underlying mechanisms. 
Keywords: Hemophilia, NAFLD, Liver Disease, Obesity, Fibroscan, Metabolic Syndrome.