Comparison of Prognostic Accuracy of Quick Sequential Organ Failure Assessment (qSOFA) Score and National Early Warning Score-2 (NEWS-2) to Predict Mortality in Patients with Sepsis or Suspected Sepsis in Emergency Department (Code-T0329)

Introduction: Sepsis is a life-threatening condition characterized by organ dysfunction due to a 
dysregulated host response to infection. Early identification and risk stratification are critical for 
improving patient outcomes. Quick Sequential Organ Failure Assessment (qSOFA) and National 
Early Warning Score-2 (NEWS-2) are widely used scoring systems for predicting mortality in 
sepsis patients. While qSOFA is commonly utilized outside intensive care settings, NEWS-2 has 
been recognized for its superior predictive accuracy in emergency settings. This study aims to 
compare the prognostic accuracy of these two scoring systems in predicting in-hospital mortality 
among patients with sepsis or suspected sepsis. 
Aims and Objectives 
Aim: 
To compare the prognostic accuracy of Quick Sequential Organ Failure Assessment (qSOFA) 
score and National Early Warning Score-2 (NEWS-2) in predicting mortality in patients with 
sepsis or suspected sepsis. 
Objectives: 
 To investigate the role of qSOFA in predicting mortality during hospitalization in patients 
with sepsis or suspected sepsis presenting to the emergency department. 
 To examine the effectiveness of NEWS-2 in predicting in-hospital mortality in patients 
with sepsis or suspected sepsis. 
 To compare qSOFA and NEWS-2 in their ability to predict in-hospital deaths among 
sepsis patients. 
Methods: A prospective observational study will be conducted in the Emergency Medicine 
Department at Rajshree Medical Research Institute, Bareilly. Patients aged >16 years with 
suspected or confirmed sepsis will be enrolled. qSOFA and NEWS-2 scores will be recorded at 
admission, and their prognostic accuracy will be assessed based on in-hospital mortality 
outcomes. Statistical analysis will be performed using SPSS software. 
Results: The study anticipates that NEWS-2 will demonstrate superior predictive accuracy 
compared to qSOFA, aligning with existing literature suggesting its enhanced sensitivity for 
early sepsis detection. 
Conclusion: Both qSOFA and NEWS-2 serve as valuable tools for sepsis prognostication. 
However, NEWS-2 may offer improved accuracy in predicting mortality, supporting its 
integration into emergency clinical protocols. 
Keywords: Sepsis, qSOFA, NEWS-2, Mortality Prediction, Emergency Medicine, Prognostic 
Accuracy.