Clinical Profile, Treatment, and Short-Term Follow-Up of Patients with Kawasaki Disease Admitted in a Tertiary Care Centre (Code-T0345)

Introduction: Kawasaki Disease (KD) is an acute vasculitic illness primarily affecting medium
sized arteries, with a significant risk of coronary artery complications if left untreated. Though 
self-limiting, untreated KD can lead to life-threatening cardiovascular issues, including coronary 
aneurysms. This study aims to analyze the clinical profile, treatment modalities, and short-term 
follow-up outcomes of KD patients admitted to a tertiary care hospital. 
Aims and Objectives:  
Aims  
 Clinical profile, treatment and short-term follow- up of patients with Kawasaki disease 
admitted in a tertiary care Centre.  
Objectives  
 To describe the different clinical features, laboratory parameters, treatment, short- term 
follow- up of patient admitted with Kawasaki disease.  
 To compare the clinical and laboratory characteristics between Complete and Incomplete 
Kawasaki Disease.  
Methods: A prospective observational study was conducted at Jorhat Medical College & 
Hospital, Assam, over one year (September 2023 - August 2024). The study included 30 
pediatric patients diagnosed with complete or incomplete KD, based on the American Heart 
Association (AHA) 2017 criteria. Data on demographics, clinical presentation, laboratory 
findings, echocardiographic features, treatment response, and short-term follow-up outcomes 
were recorded and analyzed using statistical software. 
Results: The most common clinical manifestations included fever, oral mucosal changes, 
polymorphous rash, conjunctivitis, and extremity changes. Coronary artery abnormalities (CAA) 
were observed in a subset of patients, with a higher prevalence in those with incomplete KD. 
Treatment with intravenous immunoglobulin (IVIG) significantly reduced inflammation and 
improved short-term outcomes. 
Conclusion: Early diagnosis and timely IVIG administration are crucial in reducing the risk of 
coronary complications in KD. Continuous follow-up is necessary to monitor cardiac sequelae 
and ensure optimal long-term outcomes. 
Keywords: Kawasaki Disease, vasculitis, coronary artery aneurysm, intravenous 
immunoglobulin, pediatric cardiology, short-term follow-up.