Evaluation of Estrogen Receptor (ER), Progesterone Receptor (PR), and Ki-67 Proliferation Index Across Histological Grades of Meningioma at a Tertiary Care Center (Code-T0349)

Introduction: Meningiomas are the most common intracranial tumors, originating from 
arachnoidal cap cells. Despite their predominantly benign nature, certain meningiomas 
exhibit aggressive behavior. Hormonal receptors such as estrogen (ER) and progesterone 
(PR) and the proliferation marker Ki-67 play significant roles in tumor biology. This study 
aims to analyze their expression across different meningioma grades to assess potential 
prognostic implications. 
Aims and Objectives: 
Aim: 
 The aim of this study is to investigate the correlation between various grades of 
Meningiomas with proliferation index Ki-67 and hormonal (progesterone and 
estrogen) markers, to study the frequency of occurrence of various grades and to 
correlate the Meningioma grades by using immunohistochemistry. 
Primary Objectives:  
 To analyse the Progesterone Receptor, Estrogen Receptor and Ki67  
expression by  immunohistochemistry in Meningioma. 
Secondary Objectives: 
 To study the histopathological features and to correlate the findings with 
Progesterone  Receptor,  Estrogen  Receptor expression and proliferation of 
Ki67 index.  
Methods: A prospective study was conducted in the Department of Pathology, Gajra Raja 
Medical College, Gwalior, over 1.5 years. A total of 55 histopathologically confirmed 
meningioma cases were included. Hematoxylin and eosin staining was performed for tumor 
grading, followed by IHC analysis using monoclonal antibodies against ER, PR, and Ki-67. 
Statistical analysis was performed using SPSS software. 
Results: The study expects to establish an association between PR, ER expression, and Ki-67 
proliferation index with tumor grade. Higher Ki-67 levels may indicate increased tumor 
aggressiveness, while PR positivity may have prognostic significance. 
Conclusion: The findings will contribute to understanding the prognostic and therapeutic 
significance of ER, PR, and Ki-67 in meningiomas, aiding in improved patient management 
and treatment decisions. 
Keywords: Meningioma, Estrogen Receptor, Progesterone Receptor, Ki-67, 
Immunohistochemistry, Tumor Grading