Assessment of Ocular Surface Alterations in Patients Admitted to the Intensive Care Unit at a Tertiary Care Centre in Northern India (Code-T0356)

Introduction: Patients in intensive care units (ICU) are at high risk of developing ocular 
surface disorders due to impaired protective mechanisms such as poor eyelid closure, 
decreased blink reflex, and reduced tear production. These factors can lead to complications 
like keratitis and corneal abrasions, affecting post-recovery vision and quality of life. Timely 
diagnosis and appropriate eye care measures are essential in preventing severe ocular 
morbidity. 
Aims and Objectives: 
To study ocular surface alterations in ICU admitted patients. 
Objectives:  
1. Estimate incidence of ocular surface disorder among ICU patients.  
2. Evaluate microbial pattern in case of ICU acquired infective kerato-conjunctivitis.  
3. Propose a feasible and effective eye care regimen for ICU patints 
Methods: This prospective study will be conducted at Sarojini Naidu Medical College, Agra, 
over 18 months. A sample of 270-300 ICU patients aged >17 years and admitted for >72 
hours will be included. Ocular assessments, including lagophthalmos, corneal staining, 
Schirmer’s test, and microbiological evaluation, will be performed. Statistical analysis will 
determine associations between ocular alterations and ICU parameters. 
Results: The study is expected to provide insights into the prevalence and microbial profile 
of ocular surface disorders in ICU patients, correlating these with risk factors such as 
sedation, ventilation, and prolonged ICU stay. 
Conclusion: Findings will help formulate a feasible eye care protocol to reduce ICU-related 
ocular complications, improving visual outcomes and patient quality of life. 
Keywords: Ocular surface disorders, ICU patients, corneal abrasions, keratitis, microbial 
analysis, eye care regimen.