Evaluation of Iron Status in Regular Whole-Blood Donors: Impact of Repeated Donations on Body Iron Stores (Code -T0362)

Introduction: Regular blood donation can lead to iron depletion, impacting donor well-being 
and the quality of donated blood. Hemoglobin screening alone may not detect early-stage iron 
deficiency. This study aims to assess iron status among regular blood donors to identify the 
impact of frequent donations on body iron stores. 
Aims and Objectives: 
This study aims to investigate the impact of regular blood donation on iron status 
parameters using hematological and biochemical assessments. 
Objectives: 
This study primary objective is to assess the changes in iron status, including iron 
depletion and iron deficiency, among individuals who engage in frequent blood 
donation. 
Secondary Objectives: 
1. To evaluate the levels of iron-related parameters, such as serum ferritin, 
Hemoglobin, TIBC, Serum Iron, serum Transferrin at the time of whole-blood 
donation. 
2. To examine the association between the frequency of blood donation and the 
extent of iron depletion. 
3.To contribute to the existing knowledge on strategies for managing and 
preventing iron deficiency among regular blood donors.. 
Methods: This prospective observational study, conducted over 18 months in the Department 
of Immunohematology and Blood Transfusion, includes first-time and regular voluntary 
donors. Participants are categorized based on donation frequency. Blood samples are 
analyzed for hematological parameters and iron-related biomarkers. Statistical analysis is 
performed using SPSS v20, with ANOVA and Cox regression to determine associations. 
Results: Findings will illustrate the prevalence of iron depletion in regular blood donors, with 
serum ferritin levels serving as a key indicator. The study aims to highlight differences 
between donor groups and identify risk factors contributing to iron deficiency. 
Conclusion: Understanding iron status in blood donors is essential for maintaining donor 
health and a sustainable blood supply. Implementing strategies such as iron supplementation 
and optimizing donation intervals could mitigate iron deficiency risks. 
Keywords: Blood donation, Iron deficiency, Serum ferritin, Hemoglobin, Iron depletion, 
Blood donor health.