Assessment of Salivary Lactate Dehydrogenase Levels in Individuals With and Without Oral Mucosal Disorders (Code-T0037)

Introduction: Lactate dehydrogenase (LDH) is an intracellular enzyme that plays a vital role in cellular metabolism and serves as a marker of tissue damage. In oral mucosal disorders, elevated salivary LDH levels reflect cellular injury and metabolic alterations. This study aimed to evaluate salivary LDH levels in individuals with and without oral mucosal disorders to explore its diagnostic potential.

Aim & Objective: To assess and compare salivary LDH levels in individuals with oral mucosal disorders and healthy controls, and to evaluate the correlation between LDH levels and the severity of mucosal disorders.

Methods: A cross-sectional study was conducted on 110 participants, comprising 55 individuals with clinically diagnosed oral mucosal disorders and 55 age- and sex-matched healthy controls. Saliva samples were collected and analyzed for LDH levels using a spectrophotometric assay. Clinical severity of mucosal disorders was assessed and correlated with salivary LDH levels. Data were analyzed statistically using appropriate tests.

Results: Salivary LDH levels were significantly higher in individuals with oral mucosal disorders compared to healthy controls (p<0.05). Among the mucosal disorders, severe cases demonstrated markedly elevated LDH levels. A positive correlation was observed between LDH levels and the severity of mucosal lesions.

Conclusion: Salivary LDH levels are elevated in individuals with oral mucosal disorders, reflecting tissue damage and cellular disruption. Salivary LDH holds potential as a non-invasive biomarker for the diagnosis and monitoring of oral mucosal disorders.

Keywords: Salivary biomarkers lactate dehydrogenase, oral mucosal disorders, tissue damage, non-invasive diagnostics, salivary analysis.