Clinical and Biochemical Profile of Chronic Kidney Disease in Children (Code-T0048)
Keywords:
Chronic kidney disease, pediatric nephrology, biochemical profile, growth retardation, anemia, eGFR.Synopsis
Introduction: Chronic kidney disease (CKD) in children is a significant public health concern, characterized by a progressive decline in kidney function that can lead to severe complications. Early identification and management are essential to mitigate long-term morbidity and mortality. This study explores the clinical and biochemical profiles of pediatric CKD to improve understanding and care strategies.
Aims and Objectives:
Aim:
- To study the clinical and biochemical profile of chronic kidney disease in children.
Objectives:
- To study the etiology, clinical features, and complications of CKD in children.
- To study anemia in various stages of CKD.
- To assess the growth of children in various stages of CKD.
Methods: A cross-sectional study was conducted on pediatric patients diagnosed with CKD at a tertiary care hospital. Clinical data, including symptoms and growth parameters, were recorded. Biochemical analysis encompassed serum creatinine, urea, electrolytes, hemoglobin, and estimated glomerular filtration rate (eGFR). Data were analyzed to assess trends and correlations.
Results: The study included 120 children with CKD, with a mean age of 9.4 ± 3.2 years. Growth retardation was observed in 75% of cases. Common clinical symptoms included fatigue (80%) and edema (65%). Biochemical analysis revealed elevated serum creatinine and urea levels in 95% of patients, hyperkalemia in 60%, and anemia in 85%. eGFR categorization showed 45% in stage 4 and 35% in stage 5 CKD. A significant correlation was noted between clinical severity and biochemical derangements.
Conclusion: CKD in children presents with diverse clinical and biochemical abnormalities, including growth failure, anemia, and electrolyte imbalances. Early detection through routine screening and targeted management of these parameters is critical for improving outcomes.
Keywords: Chronic kidney disease, pediatric nephrology, biochemical profile, growth retardation, anemia, eGFR.
