Multiparametric MRI Approach to Ring-Enhancing Lesions (Code-T0084)

Introduction: Ring-enhancing lesions (RELs) on MRI are commonly observed in various neurological conditions, including infections, tumors, and inflammatory disorders. Accurate identification of the underlying pathology is crucial for proper diagnosis and treatment planning. A multiparametric MRI approach, utilizing multiple imaging sequences, has shown promise in differentiating these lesions. This study aims to evaluate the effectiveness of a multiparametric MRI approach in characterizing and diagnosing ring-enhancing lesions.

Aims and Objective:

To establish a differential diagnosis and study the role of advanced Magnetic Resonance Imaging (MRI) techniques, such as Diffusion-Weighted MRI, Perfusion-Weighted MRI, and Magnetic Resonance Spectroscopy (MRS), as additional protocols alongside routine MRI protocols in the diagnostic evaluation of ring-enhancing lesions in the brain. The objectives are:
1. To improve the sensitivity of lesion detection.

1. To enhance the specificity in establishing a differential diagnosis.

Methods: A prospective study was conducted on 50 patients presenting with ring-enhancing lesions on MRI. Multiparametric MRI sequences, including T1-weighted, T2-weighted, post-contrast images, Diffusion Weighted Imaging (DWI), and Magnetic Resonance Spectroscopy (MRS), were acquired. Each lesion was analyzed for characteristics such as shape, enhancement pattern, and associated edema. Clinical data and histopathological results were used to correlate imaging findings with the final diagnosis.

Results: Multiparametric MRI demonstrated high accuracy in distinguishing between infectious, neoplastic, and inflammatory causes of ring-enhancing lesions. DWI was particularly helpful in identifying abscesses, while MRS helped differentiate between tumors and infections by detecting abnormal metabolic profiles. Post-contrast imaging and T2 sequences provided further clarity on lesion borders and surrounding edema.

Conclusion: A multiparametric MRI approach significantly improves the ability to diagnose and characterize ring-enhancing lesions, offering a comprehensive and non-invasive method to guide clinical management.

Keywords: Ring-Enhancing Lesions, Multiparametric MRI, Diffusion Weighted Imaging, Magnetic Resonance Spectroscopy, MRI Sequences, Lesion Characterization.