Evaluation of Left Ventricular Function and Cardiovascular Abnormalities in Patients with Chronic Liver Disease (Code-T0085)

Introduction: Chronic liver disease (CLD) is often associated with cardiovascular abnormalities, including altered left ventricular (LV) function, QTc prolongation, and various electrocardiographic (ECG) and echocardiographic changes. These cardiovascular manifestations may influence the clinical management and prognosis of patients with CLD. This study aims to evaluate the impact of CLD on left ventricular function and assess the correlation between these abnormalities and factors such as ascites, QTc prolongation, and disease severity.

Aims and Objectives:

1. To evaluate left ventricular function in patients with chronic liver disease.
2. To assess the correlation between left ventricular function and the presence of ascites, QTc prolongation, etiology, and severity of chronic liver disease.
3. To evaluate electrocardiographic (ECG) and echocardiographic abnormalities in patients with chronic liver disease and their correlation with the presence of ascites, etiology, and severity of chronic liver disease.

Methods: A cross-sectional study was conducted involving 100 patients diagnosed with chronic liver disease. Detailed clinical assessments were made, including measurement of left ventricular ejection fraction (LVEF) via echocardiography, ECG analysis for QTc prolongation, and evaluation of other cardiovascular abnormalities. The presence of ascites and the etiology and severity of liver disease were also recorded.

Results: The study found a significant reduction in LV function (lower LVEF) in patients with severe CLD, particularly in those with ascites. Additionally, QTc prolongation was common in these patients and correlated with the severity of liver disease. ECG and echocardiographic abnormalities were more pronounced in individuals with advanced stages of CLD.

Conclusion: Chronic liver disease is associated with significant cardiovascular abnormalities, including impaired left ventricular function and QTc prolongation. Early detection and monitoring of these abnormalities are crucial in improving the management and outcomes of CLD patients.

Keywords: Chronic Liver Disease, Left Ventricular Function, Cardiovascular Abnormalities, Ascites, QTc Prolongation, Echocardiography.